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  • Title: Synthesis, characterization and biological studies of some novel 3-fluorosalicylaldehyde based amine derivatives.
    Author: Shanmugam M, Narayanan K, Mahalakshmi M, Kabilan S, Chidambaranathan V.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2013 Dec; 116():394-400. PubMed ID: 23973585.
    Abstract:
    A series of biologically important substituted 3-fluorosalicylaldehyde derivatives (1a-h) with various primary amines were synthesized by using ionic liquid (1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide) as an efficient catalyst. A new series of Schiff base derivatives (1a-h) were synthesized and characterized by IR, NMR ((1)H, (13)C, (1)H-(1)H COSY and HSQC), mass spectra and elemental analysis. Further crystal structure of compound 1a was evaluated by single crystal X-ray diffraction techniques. All the synthesized compounds were screened for in vitro antimicrobial activity against a panel of selected bacterial and fungal strains using Streptomycin and Amphotericin B as standards. Most of the synthesized compounds demonstrated moderate effects on both antibacterial and antifungal activities at minimum inhibitory concentrations (MIC's).
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