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  • Title: Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study.
    Author: Emami S, Ghafouri E, Faramarzi MA, Samadi N, Irannejad H, Foroumadi A.
    Journal: Eur J Med Chem; 2013 Oct; 68():185-91. PubMed ID: 23974018.
    Abstract:
    Novel Mannich bases of 7-piperazinylquinolones with kojic acid and chlorokojic acid were designed as new quinolone antibacterials. All compounds showed significant in vitro antibacterial activity against both Gram-positive and Gram-negative bacteria. Particularly, chlorokojic derivative 2b was the most potent compound against Staphylococcus aureus and Pseudomonas aeruginosa (MIC values≤0.19 μg/mL). Its activity was 4-8 times more than that of standard drug norfloxacin. The molecular docking study of compound 2b further supported the molecular basis of the designed compounds.
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