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  • Title: Complex chromosome rearrangements involving 12q14 in two uterine leiomyomas.
    Author: Pandis N, Bardi G, Sfikas K, Panayotopoulos N, Tserkezoglou A, Fotiou S.
    Journal: Cancer Genet Cytogenet; 1990 Oct 01; 49(1):51-6. PubMed ID: 2397473.
    Abstract:
    Cytogenetic analysis of short-term cultures from 10 uterine leiomyomas revealed normal karyotypes in 8 and clonal complex chromosome rearrangements in 2 tumors. In both leiomyomas with clonal abnormalities, 12q14, but not 14q22-24, was involved in translocations with 1q43 in one tumor and with 12q24 in the other. Additional chromosome abnormalities were found in both cases: 1-5 rings and monosomy of chromosome 9 in case 1, and complex numerical and structural abnormalities of chromosomes 1, 6-8, 11, 13, 16, 17, and 22 in case 2. The consistent cytogenetic rearrangement of 12q14 in uterine leiomyomas, sometimes without concomitant 14q changes, indicates that a gene of critical importance for leiomyoma development may be found in this band.
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