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  • Title: The synthesis of benzo[f]isoindole-1,3-dicarboxylates via an i2-induced 1,3-dipolar cycloaddition reaction.
    Author: Li YJ, Huang HM, Dong HQ, Jia JH, Han L, Ye Q, Gao JR.
    Journal: J Org Chem; 2013 Sep 20; 78(18):9424-30. PubMed ID: 23977993.
    Abstract:
    An I2-induced 1,3-dipolar cycloaddition reaction has been developed for the synthesis of benzo[f]isoindole-1,3-dicarboxylates from quinones and N-substituted amino esters. The reaction proceeds in good to excellent yields in one step from 3 equiv of amino ester to react with the quinone structure. The utility of this transformation has been highlighted by its use for the construction of benzo[f]isoindole-1,3-dicarboxylates, which have been identified in natural products exhibiting important biological activities.
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