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  • Title: Molecular design for enhanced sensitivity of a FRET aptasensor built on the graphene oxide surface.
    Author: Ueno Y, Furukawa K, Matsuo K, Inoue S, Hayashi K, Hibino H.
    Journal: Chem Commun (Camb); 2013 Nov 14; 49(88):10346-8. PubMed ID: 23985796.
    Abstract:
    We designed a biomolecular probe for highly sensitive protein detection by modifying an aptamer with a DNA spacer. The spacer controls the distance between a fluorescence dye and a quencher, which is crucial for FRET-based sensors. We successfully demonstrated an improvement in the sensitivity of an on-chip graphene oxide aptasensor.
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