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  • Title: Spasmolytic activity of two synthetic anilide local anaesthetics.
    Author: Singh G, Mishra KC.
    Journal: Indian J Physiol Pharmacol; 1975; 19(1):34-8. PubMed ID: 239905.
    Abstract:
    Two basic anilides EA-7 and EA-8 were investigated for their antispasmodic activity against a variety of spasmogens on different tissues from different species of animals and comparison was made with lignocaine. EA-8 was found to be the most potent in this respect, followed by EA-7 and lignocaine. The antispasmodic potency does not correspond to their local anaesthetic potency. This suggests a direct depressant effect on tissues.
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