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  • Title: [Goodpasture's syndrome--disease of many faces].
    Author: Panek A, Walatek B, Sułowicz W.
    Journal: Przegl Lek; 2013; 70(4):218-23. PubMed ID: 23991562.
    Abstract:
    Pulmonary-renal syndrome (PRS) can originate from several connective tissue diseases. It belongs to the potentially life-threatening conditions. Clinically PRS is a combination of diffuse pulmonary hemorrhage and renal involvement including glomerulonephritis, nephrotic syndrome or acute renal failure. Goodpasture's syndrome accounts for approximately 20% cases of PRS. Until recently diffuse pulmonary hemorrhage connected with rapid progressive glomerulonephritis usually resulted in a very bad prognosis. However now, rapid diagnostic process (antibodies identification, kidney and pulmonary biopsy) can speed up a difficult decision of using intense immunosuppressive therapy including cyclophosphamide and methylprednisolone pulses or plasma exchanges. Simultaneously, the therapy should be supported by artificial ventilation and renal replacement therapy. In some cases such a treatment can be followed by a complete recovery from renal and pulmonary diseases. The combined therapy contributed to considerable reduction in mortality rate that recently has been achieved in PRS patients. In present paper 3 cases of Goodpasture's syndrome with different manifestations of the disease were described.
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