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  • Title: Hypoxia-inducible factor 1 alpha (HIF-1α) as a prognostic indicator in patients with gastric tumors: a meta-analysis.
    Author: Zhang ZG, Zhang QN, Wang XH, Tian JH.
    Journal: Asian Pac J Cancer Prev; 2013; 14(7):4195-8. PubMed ID: 23991975.
    Abstract:
    BACKGROUND AND OBJECTIVE: Though researched for years, the prognostic role of hypoxia-inducible factor 1 alpha (HIF-1α) in gastric cancer is still controversial. We thus undertook a systematic review to assess the relationship. METHOD: A systematically literature search of Pubmed, Embase, Web of Science, China Biological Medicine Disc and Cochrane Library was undertaken in February 2013, and the reference lists of articles were retrieved. RESULTS: 12 trials (1,555 participants) were included to assess the association between HIF-1α expression and survival. Summary hazard ratios (HRs) were calculated. HIF-1α expression was significantly correlated with poor overall survival of gastric cancer patients (HR=1.34, 95%CI: 1.13-1.58; P=0.0009), but not with poor disease free survival of gastric cancer patients (HR=1.67, 95%CI: 0.99-2.82; P=0.06). CONCLUSION: HIF-1α was associated with poor OS, but not DFS, especially for Asian patients. But studies evaluating relationships of HIF- 1α with OS and DFS in non-Asian gastric cancer patients appear needed.
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