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  • Title: Self-referencing optofluidic ring resonator sensor for highly sensitive biomolecular detection.
    Author: Li M, Wu X, Liu L, Fan X, Xu L.
    Journal: Anal Chem; 2013 Oct 01; 85(19):9328-32. PubMed ID: 23992426.
    Abstract:
    The noise-suppression techniques of label-free optical ring resonator sensors are crucial to improve their practical sensing capabilities for biochemical analysis and detection in extremely small detection concentration. We have developed a self-referencing optofluidic ring resonator (SR-OFRR) to vastly improve its sensing capability as a label-free optical biosensor. By monitoring the mode-splitting separation generated on a coupled ring resonator system, the common-mode noise is suppressed by 2 orders of magnitude without any external noise-suppression techniques. In this work, we first carried out theoretical analysis to elucidate the sensing principle and then applied the SR-OFRR biosensor to experimentally detect bovine serum albumin with a concentration detection limit on the order of 1 pg/mL (~15 fM).
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