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  • Title: Using Galleria mellonella-Candida albicans infection model to evaluate antifungal agents.
    Author: Li DD, Deng L, Hu GH, Zhao LX, Hu DD, Jiang YY, Wang Y.
    Journal: Biol Pharm Bull; 2013; 36(9):1482-7. PubMed ID: 23995660.
    Abstract:
    Candida albicans is the most common fungal pathogen. Galleria mellonella is widely used as an infection model host. Nevertheless, the G. mellonella-C. albicans infection model had not been optimized for drug evaluation before this study. In this work, we revealed that 5 × 10(5) colony forming unit (CFU)/larva was a suitable inoculum to optimize the G. mellonella-C. albicans infection model in order to evaluate antifungal agents. Using our optimized model, the antifungal effect of fluconazole, amphotericin B and flucytosine, and the synergy between amphotericin B and flucytosine were successfully verified. Thus, this study provides a rapid, inexpensive and reliable way to evaluate antifungals in vivo.
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