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  • Title: Acute and chronic effects of diphenhydramine and sertraline mixtures in Ceriodaphnia dubia.
    Author: Goolsby EW, Mason CM, Wojcik JT, Jordan AM, Black MC.
    Journal: Environ Toxicol Chem; 2013 Dec; 32(12):2866-9. PubMed ID: 23996615.
    Abstract:
    Ceriodaphnia dubia were tested to evaluate the acute and chronic interactive effects of diphenhydramine and sertraline. Observed effects were compared with 2 reference toxicity models, the concentration addition model and the independent action model. Results indicate that the 2 drugs exhibit additive toxicity in C. dubia. In some cases, individually sublethal concentrations of the chemicals resulted in 100% mortality when combined, demonstrating the potentially severe impact of trace environmental contaminants.
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