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  • Title: Practical silyl protection of ribonucleosides.
    Author: Blaisdell TP, Lee S, Kasaplar P, Sun X, Tan KL.
    Journal: Org Lett; 2013 Sep 20; 15(18):4710-3. PubMed ID: 24000770.
    Abstract:
    Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected monomers for automated RNA synthesis. Switching to the opposite enantiomer of the catalyst allows for the selective silylation of the 3'-hydroxyl, which could be used in the synthesis of unnatural RNA or for the analoging of ribonucelosides. Lastly, the procedure was extended to ribavirin a potent antiviral therapeutic.
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