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  • Title: Convergent access to bis-spiroacetals through a Sila-Stetter-ketalization cascade.
    Author: Labarre-Lainé J, Beniazza R, Desvergnes V, Landais Y.
    Journal: Org Lett; 2013 Sep 20; 15(18):4706-9. PubMed ID: 24000801.
    Abstract:
    An NHC-catalyzed sila-Stetter reaction between aliphatic acylsilanes and vinylketones bearing silyl ether substituents affords functionalized 1,4-diketones, which upon treatment under acidic conditions leads to the corresponding bis-spiroacetals. The two-step sequence may also be carried out in a one-pot operation leading to high yields of the desired bis-spiroacetals.
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