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  • Title: 2H,5H-[1]benzothiopyrano [4,3-b]pyran derivatives with platelet antiaggregating activity.
    Author: Bargagna A, Longobardi M, Mariani E, Schenone P, Losasso C, Esposito G, Falzarano C, Marmo E.
    Journal: Farmaco; 1990 Apr; 45(4):405-13. PubMed ID: 2400515.
    Abstract:
    The synthesis of some N,N-disubstituted 4-amino-3-phenyl-2H,5H-[1]benzothiopyrano [4,3-b]pyran-2-ones by reaction of phenylchloroketene with a series of N,N-disubstituted 3-aminomethylene-2,3-dihydro-4H-1-benzothiopyran-4-ones, followed by dehydrochlorination of the primary adducts with DBN, is described. Some of these compounds showed a strong platelet antiaggregating activity in vitro, superior to that of acetylsalicylic acid.
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