These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis, antibacterial, antifungal and antitubercular activities of N-pyrazolylbenzamide derivatives.
    Author: Kulkarni R, Kumar V, Babu H, Kumar K, Gaddam N, Fatima A, Muvvala S, Bhikshapathi DV, Sriram D, Garlapati A, Vishnav J, Gurav P.
    Journal: Med Chem; 2014 Mar; 10(2):220-7. PubMed ID: 24007493.
    Abstract:
    A series of new N-pyrazolylbenzamides (5a-x) were synthesized by aroylation of 5-amino-1-phenyl-3-tbutylpyrazole. The structures of synthesized compounds were established based on spectral (FTIR, (1)H NMR, ESI Mass) analysis and purity was ascertained by HPLC. The antibacterial screening revealed that seven molecules exhibited an excellent antibacterial activity and eight compounds demonstrated considerable antifungal activity. Three molecules of the series 5e, 5s and 5w were found to be highly effective against Klebsilla pneumoneia with MIC of 3.12 µg/ml. Compounds 5b, 5f, 5g and 5o exhibited significant antitubercular activity with MIC of 12.5 µg/ml.
    [Abstract] [Full Text] [Related] [New Search]