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  • Title: [In vitro use of a model for studying the effects of tumor promoters in food].
    Author: Martel P, Chaumontet C, François V, Pascal G.
    Journal: Bull Cancer; 1990; 77(5):495-9. PubMed ID: 2400823.
    Abstract:
    Two antioxidants, butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), which are widely used as food additives, have been proved in vivo to act as tumor promoters in rodent species. In order to study their mechanisms of action, BHT, BHA and phenobarbital (PB) were tested in vitro on liver epithelial cells isolated from 2-acetylaminofluorene-initiated rats. Interactions of BHT 3 x 10(-6) to 3 x 10(-5) M, BHA 10(-5) to 10(-4) M and of PB 10(-4) to 10(-3) M with cell growth on plastic dishes or in agarose, and with the expression of different proteins (gamma-glutamyltranspeptidase, cytoskeletal proteins, fibronectin) were followed.
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