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  • Title: Early detection of central visual function decline in cone-rod dystrophy by the use of macular focal cone electroretinogram.
    Author: Galli-Resta L, Piccardi M, Ziccardi L, Fadda A, Minnella A, Marangoni D, Placidi G, Resta G, Falsini B.
    Journal: Invest Ophthalmol Vis Sci; 2013 Oct 09; 54(10):6560-9. PubMed ID: 24008410.
    Abstract:
    PURPOSE: To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD). METHODS: A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly for 6.0 ± 3.1 years. Macular focal cone ERG was evoked by a flickering uniform red field overlaying the central 18° of visual field. RESULTS: Macular focal cone ERG follow-up allowed a clear-cut identification of CRD patients as stationary or progressive, in agreement with visual acuity follow-up. In all progressive patients, fERG declined whenever visual acuity declined, and--in 50% of the cases--fERG loss anticipated acuity loss of several years. CONCLUSIONS: Macular focal cone ERG represents a sensitive assay to detect, categorize, and follow the progression of central retinal dysfunction in CRD. Its use as a diagnostic tool in CRD may help anticipate, for an individual patient, the likelihood and rate of further disease progression before visual acuity loss has occurred.
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