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  • Title: Iridium-catalyzed cycloaddition of azides and 1-bromoalkynes at room temperature.
    Author: Rasolofonjatovo E, Theeramunkong S, Bouriaud A, Kolodych S, Chaumontet M, Taran F.
    Journal: Org Lett; 2013 Sep 20; 15(18):4698-701. PubMed ID: 24011015.
    Abstract:
    Iridium dimer complexes were found to catalyze the [3 + 2] cycloaddition reaction of azides with bromoalkynes, yielding 1,5-disubstituted 4-bromo-1,2,3-triazoles in reasonable to excellent yields under mild conditions. The reaction offers a direct route to new 1,4,5-trisubstituted triazoles.
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