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  • Title: [Expression and significance of PD-1 on CD4(+); and CD8(+); T cells from the peripheral blood of patients with systemic lupus erythematosus].
    Author: Wang Y, Xie C, Sun M, Chai J, Zhou Y, Chen Y, Tang J, Li B.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2013 Sep; 29(9):962-5. PubMed ID: 24011159.
    Abstract:
    OBJECTIVE: To detect the expression of programmed death-1 (PD-1) on CD4(+); and CD8(+); T cells from the peripheral blood of patients with systemic lupus erythematosus (SLE) and analyze its clinical implications. METHODS: The expression of PD-1 on the CD4(+); and CD8(+); T cells were examined in 51 SLE patients and 38 healthy controls (HCs) by flow cytometry. The proportions of PD-1 positive CD4(+); and CD8(+); T cells were compared not only between inactive or active SLE patients and HCs, but also between patients with and without lupus nephritis. The correlations of PD-1 expression with clinical manifestations and laboratory findings were analyzed. RESULTS: The proportions of CD4(+); PD-1(+); T cells significantly increased in active SLE patients as compared with HCs and inactive SLE ones (all P<0.05). The proportions of CD8(+); PD-1(+); T cells were significantly higher in active and inactive SLE patients than those in HCs (all P<0.05). The numbers of CD4(+); PD-1(+); and CD8(+); PD-1(+); T cells in SLE patients with nephritis were significantly higher than those in patients without nephritis (P<0.01). In SLE patients, the numbers of CD4(+);PD-1(+); and CD8(+);PD-1(+); T cells were significantly higher in ones with positive anti-dsDNA, anti-Sm, and anti-nucleosome antibodies than in corresponding negative ones; the proportions of CD4(+); PD-1(+); and CD8(+); PD-1(+); T cells were positively correlated with SLEDAI score and the amount of proteinuria, but were negatively correlated with complement C3. CONCLUSION: The aberrations of CD4(+); PD-1(+); and CD8(+); PD-1(+); T cells were observed in patients with SLE. Increased numbers of CD4(+); PD-1(+); and CD8(+); PD-1(+); T cells were correlated with increased disease activity and the production of anti-self antibodies.
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