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  • Title: Electroencephalographic features of benign adult familial myoclonic epilepsy.
    Author: Toyota T, Akamatsu N, Tanaka A, Tsuji S, Uozumi T.
    Journal: Clin Neurophysiol; 2014 Feb; 125(2):250-4. PubMed ID: 24011985.
    Abstract:
    OBJECTIVE: To investigate electroencephalographic (EEG) features of benign adult familial myoclonic epilepsy (BAFME). METHODS: We reviewed interictal EEG features in patients with BAFME treated between April 2005 and November 2012 at a tertiary referral center. The diagnostic criteria for BAFME were the presence of infrequent generalized tonic-clonic seizures, myoclonus or myoclonic seizures, and autosomal dominant inheritance. Interictal EEG findings of epilepsy with generalized tonic-clonic seizure only (EGTCS) were reviewed for comparison. We randomly selected 10 generalized spike/polyspike and wave complexes (GSW) for each BAFME patient and measured the duration of them. Photic stimulation and hyperventilation were performed in all. RESULTS: Nineteen (eight men, 11 women) patients with BAFME were included in this study. The mean frequency of GSW was 4.3±1.0Hz (mean±SD, n=14) in BAFME and 3.2±0.8Hz (n=10) in EGTCS. There was a statistically significant difference (p=0.008) between the two. Photoparoxysmal responses (PPR) were noted in 18 (95%) patients with BAFME but 1 (10%) with EGTCS. CONCLUSION: Faster frequency of GSW, compared with that in EGTCS, accompanied by PPR may be characteristic EEG features of BAFME. SIGNIFICANCE: These findings may lead the diagnosis of BAFME.
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