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  • Title: Targeting receptor tyrosine kinases in solid tumors.
    Author: Zhang J, Hochwald SN.
    Journal: Surg Oncol Clin N Am; 2013 Oct; 22(4):685-703. PubMed ID: 24012395.
    Abstract:
    Tyrosine kinase (TK) cascades are involved in all stages of tumorigenesis through modulation of transformation and differentiation, cell-cycle progression, and motility. Advances in molecular targeted drug development allow the design and synthesis of inhibitors targeting cancer-associated signal transduction pathways. Potent selective inhibitors with low toxicity can benefit patients with local and metastatic malignancies. This article evaluates information on solid tumor-related TK signaling and inhibitors, including receptor TK signal pathways that lead to successful application in clinical settings, properties of recently approved TK-inhibitor drugs for the treatment of solid tumors, and potential TK pathways for future therapeutic interventions.
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