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  • Title: Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA.
    Author: Haukanes BI, Szajko K, Helland DE.
    Journal: FEBS Lett; 1990 Sep 03; 269(2):389-93. PubMed ID: 2401365.
    Abstract:
    The cleavage efficiency of spermidine and its acetyl derivatives (N1-acetylspermidine and N8-acetylspermidine) at apurinic sites in DNA were examined by PAGE-urea analysis. The three polyamines induced different rates of cleavage when compared at 1 mM concentrations. The order of effectiveness were: spermidine greater than N8-acetylspermidine greater than N1-acetylspermidine. Thus a decrease in efficiency was observed when the first order amino-groups of spermidine were blocked. The N-8amino-group of spermidine was less effective in inducing cleavage at AP-sites than the N1-amino-group. Among several proposed models of polyamine-DNA interactions, our results can best be explained by the model postulated by Liquori et al.
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