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  • Title: Lymphocytotoxic antibodies in patients with systemic lupus erythematosus & their household contacts.
    Author: Vasan RS, Mehra NK, Malaviya AN, Chaudhuri TK.
    Journal: Indian J Med Res; 1990 Jun; 92():147-50. PubMed ID: 2401534.
    Abstract:
    Twenty patients with systemic lupus erythematosus (SLE) and their 51 household contacts were screened for the presence of lymphocytotoxic antibodies. A high prevalence of lymphocytotoxic antibodies (LCTAB) was observed in the patients (80% against T cells and 100% against B cells). The antibodies carried specificity for HLA-B5/35 and HLA-DR2/DR3. A high prevalence of LCTAB was also observed in contacts (55% LCTAB-T cells, 88% LCTAB-B cells) with no difference being seen between consanguineous and non-consanguineous male or female relatives.
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