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  • Title: [The effect of local anesthetics on the electric properties of black flat bilayers].
    Author: Fedorov GE, Il'iushenok AS, Korolev NP, Mil'gram VD, Gus'kova RA, Kondakov EV, Osipov VI, Ivanov UU.
    Journal: Izv Akad Nauk SSSR Biol; 1990; (3):353-8. PubMed ID: 2401768.
    Abstract:
    The effect of some local anesthetics on conductance of bilayer lipid membranes made of egg yolk lecithin has been studied. Low concentrations of anesthetics were shown to gradually increase the integral conductance of bilayers. This effect is connected with the protonophore activity of the tested anesthetics and it caused the stabilization of the bilayers. High concentrations of anesthetics caused destabilization of membranes and formed zones of nonselective increased conductance.
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