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  • Title: Pancreatic lipase inhibitory stilbenoids from the roots of Vitis vinifera.
    Author: Kim YM, Lee EW, Eom SH, Kim TH.
    Journal: Int J Food Sci Nutr; 2014 Feb; 65(1):97-100. PubMed ID: 24020412.
    Abstract:
    Bioassay-guided isolation of an aqueous methanolic extract of Vitis vinifera using pancreatic lipase inhibitory activity led to isolation of seven stilbenoids, wilsonol C (1), heyneanol A (2), ampelopsin A (3), pallidol A (4), cis-piceid (5), trans-piceid (6) and trans-resveratrol (7). The structures were established on the basis of NMR and MS spectroscopic data interpretation. All isolates were evaluated for their inhibitory effects on pancreatic lipase, and stilbenoid 1 exhibited potent inhibitory effect on pancreatic lipase with IC₅₀ values of 6.7 ± 0.7 µM.
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