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  • Title: Multiplex ligation-dependent probe amplification (MLPA)--new possibilities of prenatal diagnosis.
    Author: Massalska D, Bijok J, Zimowski JG, Jóźwiak A, Jakiel G, Roszkowski T.
    Journal: Ginekol Pol; 2013 Jun; 84(6):461-4. PubMed ID: 24032265.
    Abstract:
    Multiplex Ligation-dependent Probe Amplification (MLPA) is a relatively new method of molecular diagnosis. It enables a relative quantitative assessment of up to 50 different PCR amplicons in one reaction by the use of a very small amount of examined DNA. Nowadays MLPA is becoming a very helpful tool in prenatal diagnosis and is widely used for the detection of aneuploidies, familial single gene disorders, common microdeletion syndromes, sub-telomeric alterations and identification of marker chromosomes in fetuses. This review demonstrates possible applications of MLPA in prenatal diagnosis.
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