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  • Title: Increased liver alanine in the tumour-bearing host. Altered levels of some enzymes involved in alanine metabolism.
    Author: Goodlad GA, Jaffray E, Loudon K, Clark CM.
    Journal: Biochem Int; 1990; 21(2):279-87. PubMed ID: 2403367.
    Abstract:
    A 2-fold increase in hepatic alanine concentration was observed in rats bearing a Walker 256 carcinoma growing sub-cutaneously. Decreases were observed in the activities of both cytosolic and mitochondrial isozyme forms of L-alanine-2-oxoglutarate aminotransferase. Activities of two enzymes involved in a secondary pathway of haem synthesis involving alanine, L-alanine-4,5-dioxovalerate aminotransferase and the NADP-requiring isozyme form of 4-oxo-5-hydroxyvalerate dehydrogenase were also reduced but there was no change in liver porphyrin concentration. L-alanine-glyoxalate aminotransferase activity was unaffected. The results are discussed in relation to the utilisation of alanine as a gluconeogenic substrate in the tumor-bearing host.
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