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  • Title: Effect of fatty-acyl-CoAs on the elongation of saturated fatty acid in porcine aorta microsomes.
    Author: Murakami K, Yoshida S, Takeshita M.
    Journal: Biochem Int; 1990; 21(2):297-304. PubMed ID: 2403369.
    Abstract:
    The microsomal elongation system from porcine aorta for longchain fatty-acyl-CoAs was investigated. Palmitoleoyl-CoA (16:1-CoA), oleoyl-CoA (18:1-CoA), and eicosenoyl-CoA (20:1-CoA) remarkably depressed the elongation activity for 16:0-CoA in aorta microsomes by 44.8, 52.4, and 43.7% of the control activity, respectively. Saturated and polyunsaturated fatty-acyl-CoAs had little effect on the 16:0-CoA elongation activity. These results indicate that monounsaturated long-chain fatty acyl-CoAs can regulate the synthesis of saturated fatty acids in the vessel walls.
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