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  • Title: Ingestion of thermally oxidized sunflower oil decreases postprandial lipemia mainly in younger individuals.
    Author: Manning PJ, Sutherland WH, Manning AE, de Jong SA, Berry EA.
    Journal: Nutr Res; 2013 Sep; 33(9):711-8. PubMed ID: 24034570.
    Abstract:
    Animal studies have shown that diets rich in thermally oxidized fat increase glucose and decrease insulin and triglyceride (TG) concentrations in the blood. We hypothesized that ingestion of a potato meal rich in thermally oxidized sunflower oil (TOSO) would decrease postprandial concentrations of insulin, incretins, and TG and increase plasma glucose concentrations. Twenty healthy subjects aged 22 to 70 years consumed meals rich in TOSO or unheated sunflower oil and containing paracetamol (1.5 g) in a randomized, crossover trial. Blood samples were taken at baseline and 10, 20, 30, 60, 90, and 120 minutes after the meals and glucose, insulin, TG, nonesterified fatty acids, glucagon-like polypeptide-1, glucose-independent polypeptide, and paracetamol (as a marker of gastric emptying) were measured in plasma or serum. The incremental areas under the curve of glucose, insulin, nonesterified fatty acid, incretins, and paracetamol levels were not significantly different between the meals. Plasma TG incremental area under the curve was 44% lower after the TOSO meal at a marginal level of significance (P = .06) in the total study population and was significantly (P = .04) and 61% lower in those of median age and younger (n = 11). These data suggest that ingestion of TOSO may acutely decrease plasma TG mainly in younger individuals and does not acutely affect glucose and insulin metabolism or gastric emptying in healthy subjects.
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