These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Benzohydroxamic acids as potent and selective anti-HCV agents.
    Author: Kozlov MV, Kleymenova AA, Romanova LI, Konduktorov KA, Smirnova OA, Prasolov VS, Kochetkov SN.
    Journal: Bioorg Med Chem Lett; 2013 Nov 01; 23(21):5936-40. PubMed ID: 24035094.
    Abstract:
    A diverse collection of 40 derivatives of benzohydroxamic acid (BHAs) of various structural groups were synthesized and tested against hepatitis C virus (HCV) in full-genome replicon assay. Some of these compounds demonstrated an exceptional activity, suppressing viral replication at sub-micromolar concentrations. The compounds were inactive against key viral enzymes NS3, and NS5B in vitro assays, suggesting host cell inhibition target(s). The testing results were consistent with metal coordination by the BHAs hydroxamic group in complex with a target(s). Remarkably, this class of compounds did not suppress poliomyelitis virus (PV) propagation in RD cells indicating a specific antiviral activity of BHAs against HCV.
    [Abstract] [Full Text] [Related] [New Search]