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  • Title: What constitutes an adequate antidepressant trial for fluoxetine?
    Author: Schweizer E, Rickels K, Amsterdam JD, Fox I, Puzzuoli G, Weise C.
    Journal: J Clin Psychiatry; 1990 Jan; 51(1):8-11. PubMed ID: 2403998.
    Abstract:
    One hundred and eight patients with major depression were treated with fluoxetine 20 mg/day for 3 weeks. Patients who failed to respond to this open-label treatment were randomly assigned either to receive fluoxetine 60 mg/day for 5 weeks or to continue treatment with fluoxetine 20 mg/day for an additional 5 weeks. Both treatment groups demonstrated a statistically significant reduction in depressive symptoms, indicating that continued treatment with low-dose fluoxetine may be as effective as an increase in dose in achieving a favorable clinical outcome.
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