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  • Title: [Diagnostic value of BRAFV600E and RET/PTC oncogenes in thyroid nodule aspirates].
    Author: Guerra A, Carrano M, Angrisani E, Vitale M.
    Journal: Recenti Prog Med; 2013; 104(7-8):415-9. PubMed ID: 24042420.
    Abstract:
    Fine-needle aspiration cytology (FNC) is the primary means to distinguish benign form malignant nodules. Aim of this study is to evaluate the diagnostic value of BRAF(V600E) and RET/PTC oncogenes in a large cohort of thyroid nodules with inconclusive FNC. We searched for BRAF(V600E) and RET/PTC in 299 thyroid nodule aspirates then removed by surgery. RET/PTC demonstrated a poor specificity. The search for BRAF(V600E) demonstrated to be useful in 25 cases, identifying a PTC in 2 false negative, 2 inadequate, 11 indeterminate and 10 suspicious FNC. Detection of BRAF(V600E) revealed to be a useful tool to refine inconclusive cytology.
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