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  • Title: Structure-activity relationship of carbamate-linked cationic lipids bearing hydroxyethyl headgroup for gene delivery.
    Author: Zhi D, Zhang S, Qureshi F, Zhao Y, Cui S, Wang B, Chen H, Yang B, Zhao D.
    Journal: Colloids Surf B Biointerfaces; 2013 Dec 01; 112():537-41. PubMed ID: 24055287.
    Abstract:
    A novel series of carbamate-linked cationic lipids containing hydroxyl headgroup were synthesized and included in formulations for transfection assays. The DNA-lipid complexes were characterized for their ability to bind DNA, their size, ζ-potential and cytotoxicity. Compared with our previously reported cationic transfection lipid DDCDMA lacking the hydroxyl group and the commercially available, these cationic liposomes exhibited relatively higher transfection efficiency.
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