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  • Title: Rapid initiation of neurite outgrowth onto laminin from explants of adult mouse retina induced by optic nerve crush.
    Author: Meyer RL, Miotke J.
    Journal: Exp Neurol; 1990 Mar; 107(3):214-21. PubMed ID: 2407545.
    Abstract:
    One optic nerve of an adult mouse was crushed in the orbit. After 8 days, both retinas were explanted onto laminin-coated coverslips. Within 24 h, neurites grew out onto this substrate from explants with prior crush and by 48 h two-thirds of explants had neurites. On polylysine or plain glass, outgrowth was generally not seen until 48 h and this was significantly reduced compared to laminin. Explants without optic nerve crush did not extend neurites until about 5 days later. We suggest that axotomy induces a time-dependent regenerative response in adult mammalian retinal ganglion cells which includes the expression of laminin responsiveness.
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