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  • Title: Cytotoxicity of naturally occurring rhamnofolane diterpenes from Jatropha curcas.
    Author: Liu JQ, Yang YF, Li XY, Liu EQ, Li ZR, Zhou L, Li Y, Qiu MH.
    Journal: Phytochemistry; 2013 Dec; 96():265-72. PubMed ID: 24079824.
    Abstract:
    Twelve rhamnofolane diterpenoids, including curcusecons A-E with unusual seco-rhamnofolane skeletons, curcusones F-J, 4-epi-curcusone E, and 3-dehydroxy-2-epi-caniojane, together with seven known analogues, curcusones A-E, jatrogrossidione, and 2-epi-jatrogrossidione, were isolated from the roots of Jatropha curcas. Their structures were determined by extensive spectroscopic methods, and the relative stereochemistry of curcusecon B was further confirmed by X-ray crystallographic data. Their cytotoxity against five human cancer cells was studied and the results indicated that the dienone system in ring B was essential for cytotoxicity of these compounds.
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