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  • Title: Antibiotic-induced autoactivation of IS256 in Staphylococcus aureus.
    Author: Schreiber F, Szekat C, Josten M, Sahl HG, Bierbaum G.
    Journal: Antimicrob Agents Chemother; 2013 Dec; 57(12):6381-4. PubMed ID: 24080654.
    Abstract:
    The 3' end of rsbU, encoding the positive regulator of the stress factor sigma B, was identified as a hot spot for spontaneous IS256 insertion in Staphylococcus aureus SA137/93G. Interestingly, subinhibitory concentrations of chloramphenicol in combination with heat stress, as well as linezolid and spectinomycin at physiological temperatures, selected for such rsbU::IS256 insertion mutants. In consequence of the inactivation of rsbU, the IS256 transposition frequency was increased 4-fold in S. aureus HG001.
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