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  • Title: Aphasia, family history, and the longitudinal course of senile dementia of the Alzheimer type.
    Author: Knesevich JW, Toro FR, Morris JC, LaBarge E.
    Journal: Psychiatry Res; 1985 Mar; 14(3):255-63. PubMed ID: 2408291.
    Abstract:
    Aphasia, was present in a majority of subjects in a longitudinal study of 43 subjects with senile dementia of the Alzheimer type. Aphasic subjects had a more rapidly progressive course but a lower prevalence of familial cases than the study group, other study groups, or the nonaphasic subjects. Conversely, the lack of aphasia was associated with a higher prevalence of familial cases and a slower rate of progression. It is concluded that senile dementia of the Alzheimer type is a heterogeneous disorder in which the presence of aphasia early in the course signifies a nonfamilial, rapidly progressive variety of illness.
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