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  • Title: Production of 6-hydroxydopa by human tyrosinase.
    Author: Hansson C, Rorsman H, Rosengren E, Wittbjer A.
    Journal: Acta Derm Venereol; 1985; 65(2):154-7. PubMed ID: 2408419.
    Abstract:
    A tyrosinase obtained from cultured human melanoma cells was found to oxygenate 2,4-dihydroxyphenylalanine to the strongly cytotoxic amino acid 6-hydroxydopa (2,4,5-trihydroxyphenylalanine). The oxygenation was dependent on the presence of a reducing co-substrate such as dopa or dopamine. The rate of oxygenation of 2,4-dihydroxyphenyl-D,L-alanine was similar to that of L-tyrosine, the normal substrate of tyrosinase. The enzymatic reaction demonstrated may prove of value in the chemotherapy of human melanoma.
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