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  • Title: Presynaptic membrane retrieval and endosome biology: defining molecularly heterogeneous synaptic vesicles.
    Author: Morgan JR, Comstra HS, Cohen M, Faundez V.
    Journal: Cold Spring Harb Perspect Biol; 2013 Oct 01; 5(10):a016915. PubMed ID: 24086045.
    Abstract:
    The release and uptake of neurotransmitters by synaptic vesicles is a tightly controlled process that occurs in response to diverse stimuli at morphologically disparate synapses. To meet these architectural and functional synaptic demands, it follows that there should be diversity in the mechanisms that control their secretion and retrieval and possibly in the composition of synaptic vesicles within the same terminal. Here we pay particular attention to areas where such diversity is generated, such as the variance in exocytosis/endocytosis coupling, SNAREs defining functionally diverse synaptic vesicle populations and the adaptor-dependent sorting machineries capable of generating vesicle diversity. We argue that there are various synaptic vesicle recycling pathways at any given synapse and discuss several lines of evidence that support the role of the endosome in synaptic vesicle recycling.
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