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  • Title: An immunohistological study of HLA antigen expression by gestational choriocarcinoma.
    Author: Sunderland CA, Sasagawa M, Kanazawa K, Stirrat GM, Takeuchi S.
    Journal: Br J Cancer; 1985 Jun; 51(6):809-14. PubMed ID: 2408648.
    Abstract:
    Two cases of gestational choriocarcinoma have been examined for the expression of HLA and trophoblast antigens using the indirect immunoperoxidase technique on frozen tissue sections. Approximately 40-70% of tumour cells express MHC Class I antigen as detected by a panel of antibodies to monomorphic, or framework, MHC Class I antigenic determinants. Evidence in one case suggests that most of these cells may not express the paternal, polymorphic HLA antigenic determinants but that a small subpopulation do carry the fully antigenically active molecule. These latter may give rise to patient anti-paternal HLA antibodies. Class II (HLA DR or DC) antigens are expressed by none, or very few, tumour cells.
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