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  • Title: Tangier disease apolipoprotein A-I compared with normal plasma A-I using monoclonal antibodies.
    Author: Weech PK, Frohlich J, Marcel YL, N'Guyen TD, Milne RW.
    Journal: Biochim Biophys Acta; 1985 Jul 09; 835(2):402-7. PubMed ID: 2408675.
    Abstract:
    The molecular defect in Tangier disease is unknown. We have compared the electrophoretic and immunoreactive properties of Tangier disease and normal apolipoprotein A-I using four monoclonal antibodies. We verified that the molecular weight, pI and CNBr-cleaved fragments of Tangier disease and normal apolipoprotein A-I were not different, excluding the possibility that dimers, aggregates or fragments of apolipoprotein A-I could be responsible for its rapid catabolism in this disease.
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