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  • Title: [Mechanisms of the regulation of the biological activity of the cell by 2',5-oligoadenylate].
    Author: Itkes AV, Tunitskaia VL, Severin ES.
    Journal: Biokhimiia; 1985 Apr; 50(4):531-42. PubMed ID: 2408679.
    Abstract:
    The problems of regulation of biological activity of the cell, in particular, of such complicated processes as cell growth, differentiation, etc., rank highest among the most burning problems of present-day biology. A great majority of regulatory systems have been discovered, which control the biological activity of the cell. Among those, a most multifunctional and thoroughly investigated one is the cAMP system. The mechanisms of cAMP-dependent regulation, cAMP-dependent enzymes and other aspects of the system function have become the subject of numerous experimental papers, reviews and monographs. Another regulatory system which presently attracts the wide attention of investigators is the 2',5'-oligoadenylate system. The aim of the present review is to summarize the current data on the action mechanism and biological significance of 2',5'-oligoadenylate. Besides, the authors analyze some experimental results concerning the mechanisms of interaction and mutual regulation of the two above-mentioned systems.
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