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  • Title: Anticoagulant activity of dextran derivatives. Part II: Mechanism of thrombin inactivation.
    Author: Fischer AM, Mauzac M, Tapon-Bretaudiere J, Jozefonvicz J.
    Journal: Biomaterials; 1985 May; 6(3):198-202. PubMed ID: 2408688.
    Abstract:
    The mechanism of anticoagulant activity of dextrans substituted with carboxylic and benzylamide sulphonate groups is studied by various coagulation tests. These derivatives exhibit a heparin-like antithrombic activity which requires the presence of antithrombin III; however they are less effective than heparin on a weight basis. They also exert a direct antithrombic activity by an antithrombic III independent pathway; but this action is negligible compared to the thrombin inhibition observed in the presence of antithrombin III. Dextran derivatives have been prepared with antithrombic properties similar to those of heparin.
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