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  • Title: Effect of cyclosporine A on procoagulant activity in mononuclear blood cells and monocytes in vitro.
    Author: Carlsen E, Mallet AC, Prydz H.
    Journal: Clin Exp Immunol; 1985 May; 60(2):407-16. PubMed ID: 2408804.
    Abstract:
    Monocytes and macrophages synthesize thromboplastin when induced by a number of compounds. Our experiments show that cyclosporine A (CyA) enhances the synthesis of procoagulant activity in monocytes and in whole mononuclear cells (MNC) about two-fold when phytohaemagglutinin (PHA) is the stimulant. The enhancement is inhibited by actinomycin D and cycloheximide. CyA alone had no effect, but in the presence of PHA or phorbol ester CyA induces or enhances the synthesis of a vitamin K-dependent procoagulant in the MNC cultures. This procoagulant acts synergistically with thromboplastin synthesized in the same cultures.
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