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  • Title: Dihydropyridine Ca2+ agonists and channel blockers interact in the opposite manner with photogenerated unpaired electrons.
    Author: Marinov BS, Saxon ME.
    Journal: FEBS Lett; 1985 Jul 08; 186(2):251-4. PubMed ID: 2408923.
    Abstract:
    Interaction of Ca2+-channel antagonists (felodipine, ryocidil, verapamil, diltiazem) and agonists (dihydropyridine derivatives Bay K 8644 and CGP 28392) was studied by the methods of absorption spectroscopy. Ca2+-channel antagonists were found to act as electron donors, the agonists being electron acceptors in the interaction with dye free radicals in solution. Redox transitions in channel-forming protein were proposed as a possible mechanism of the modulation of channel activity by the compounds tested.
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