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  • Title: Anti-myelin basic protein antibody in experimental allergic optic neuritis and encephalomyelitis.
    Author: Robin JB, Phillips TM, Rao NA.
    Journal: Ophthalmic Res; 1985; 17(3):174-80. PubMed ID: 2409498.
    Abstract:
    We produced demyelinating optic neuritis and encephalomyelitis in juvenile strain 13 guinea pigs by sensitization with optic nerve myelin. Three distinct clinical courses were noted: a severe, acute optic neuritis associated with a rapidly fatal encephalomyelitis; a mild, chronic optic neuritis with a nonfatal encephalomyelitis; and an initially mild disease followed by an acute exacerbation of optic neuritis and fatal encephalomyelitis. Clinically mild disease was associated with elevated levels of anti-myelin basic protein antibody, while severe disease was associated with extremely low antibody levels.
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