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  • Title: The solubility of 2,2',4,4',5,5'-hexachlorobiphenyl in heparinized blood and plasma and in solutions of different plasma components.
    Author: Willebrand T, Kihlström I.
    Journal: Acta Pharmacol Toxicol (Copenh); 1985 Mar; 56(3):228-32. PubMed ID: 2409743.
    Abstract:
    The solubility of 2,2',4,4',5,5'-hexachlorobiphenyl (HCB) in heparinized blood from guinea-pig, heparinized plasma from mouse and in solutions of Intralipid, bovine serum albumin (BSA) and in gammaglobulin was examined by studying the equilibrium between HCB adsorbed to a test tube wall and HCB in the aqueous phase. After 24 hours of incubation at 37 degrees the highest concentration of HCB was found in the Intralipid solution, the lowest one in the gammaglobulin solution. Blood and plasma were able to dissolve equivalent concentration of HCB. One conclusion of these experiments is that the largest part of HCB in blood is bound to albumin. The explanation of different patterns of uptake to solutions of Intralipid and BSA is discussed.
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