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  • Title: Plasma membrane fluidity studies by fluorescence polarization in rat mast cells stimulated by compound 48/80.
    Author: Kuhry JG, Bronner C, Amellal M, Landry Y.
    Journal: Agents Actions; 1985 Apr; 16(3-4):109-12. PubMed ID: 2409755.
    Abstract:
    Plasma membrane fluidity measurements were performed on purified living mast cells using a novel non-permeant fluorescence polarization probe TMA-DPH, upon stimulation by compound 48/80. The fluorescence anisotropy increased rapidly after treatment by 48/80 in a dose-dependent way. The effect was found to be specific for mast cells; it was inhibited by the histamine release antagonist FR 7534 in a correlative manner. The role of calcium was examined. The results brought evidence for a plasma membrane fluidity decrease induced by 48/80; a biphasic mechanism was inferred for the histamine release process.
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