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  • Title: Inhibitory effect of lysophosphatidylcholine on the histamine release from rat peritoneal mast cells.
    Author: Mio M, Ikeda A, Akagi M, Tasaka K.
    Journal: Agents Actions; 1985 Apr; 16(3-4):113-7. PubMed ID: 2409756.
    Abstract:
    Histamine release from isolated rat peritoneal mast cells induced by compound 48/80 (0.5 microgram/ml) or antigen-antibody reaction was inhibited by lysophosphatidylcholine in a dose-dependent fashion at concentrations up to 4 microM. Within the same range of concentration, lysophosphatidylcholine exhibited a membrane-stabilizing action on the model membrane systems decreasing the permeability of lipid bilayer and the fluidity of liposomal membrane in the liquid crystalline state. At concentrations higher than 8 microM, lysophosphatidylcholine damaged the cell membrane and subsequently histamine was released. It was assumed that lysophosphatidylcholine may act as an endogenous membrane stabilizer inhibiting histamine release in normal mast cells.
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