These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Behaviorally specific versus non-specific suppression of accumbens shell-mediated feeding by ipsilateral versus bilateral inhibition of the lateral hypothalamus.
    Author: Urstadt KR, Coop SH, Banuelos BD, Stanley BG.
    Journal: Behav Brain Res; 2013 Nov 15; 257():230-41. PubMed ID: 24100119.
    Abstract:
    The nucleus accumbens shell (AcbSh) and lateral hypothalamus (LH) are linked in the control of food intake. Pharmacological inhibition of the LH may block AcbSh-elicited feeding, but the behavioral phenotype associated with this feeding suppression is unknown. To examine this phenotype, adult male Sprague-Dawley rats were implanted with three cannulas - one unilaterally in the AcbSh and two bilaterally in the LH - to allow for central drug injections. The AcbSh received injections of the AMPA receptor antagonist DNQX or the GABAA receptor agonist muscimol, while the LH received injections of the NMDA receptor antagonist D-AP5 or muscimol. Eating, drinking, grooming, locomotion, quiescence, and sleeping behaviors were measured every minute for 60 min post-injection. From these observational data, feeding bout durations, feeding frequency, and latency to feed were determined. AcbSh muscimol or DNQX increased food intake by increasing feeding bout durations and frequency and decreasing latency to feed. D-AP5 or muscimol, injected into the LH bilaterally or ipsilateral to the AcbSh injection, reversed these AcbSh-mediated effects. Though bilateral LH D-AP5 or muscimol injections blocked feeding responses, they also hastened onset of sleep. In contrast, ipsilateral LH D-AP5 or muscimol injections suppressed AcbSh-mediated feeding behaviors without substantially altering sleeping or other behaviors. These results suggest bilateral LH inhibition via NMDA receptor blockade or GABAA receptor activation produces behavioral effects that might indirectly suppress feeding, but ipsilateral LH inhibition through these receptors suppresses AcbSh AMPA and GABAA receptor-mediated feeding specifically. This evidence strengthens the concept of a feeding-specific association between these regions.
    [Abstract] [Full Text] [Related] [New Search]